Proposal for rejuvenating and beautifying your skin with exosome therapy from the cosmetic dermatology skin regeneration clinic
Exosome & MSC regenerative therapy improves cell rejuvenation, particularly addressing the weakened condition of your skin cells.
Exosome-based cosmetic treatments can address various aging effects such as wrinkles, sagging, enlarged pores, acne scars, and skin conditions, effectively enhancing skin texture and firmness.
For instance, one of the causes of enlarged pores or the appearance of a “strawberry nose” is the insufficient or weakened fibroblast cells, which affect the skin’s elasticity and firmness.
To maintain an adequate number of fibroblast cells, our bodies perform various functions. Exosomes serve as a fundamental treatment by supplementing various substances that aid in these functions.
These substances include exosomes derived from the supernatant used in the cultivation of human stem cells, known as「SCS」exosomes, as well as「HGF」exosomes derived from placental stem cell cultivation, both of which are utilized in our clinic.
Exosomes contain a high concentration of growth factors (cytokines) that promote the circulation cycle, or turnover, of healthy cells. In conventional exosome therapy, there are methods such as direct injection into the skin or intravenous injection.
Exosomes secreted from cells not only exist between cells but also circulate throughout the body fluids (blood, cerebrospinal fluid, placenta, and amniotic fluid). One of the important functions of exosomes is their involvement in intercellular communication. It has been reported that exosomes contain nucleic acids, proteins, etc., and the nucleic acids (microRNA and messenger RNA) secreted by cells are transferred to recipient cells via exosomes. Therefore, exosomes are considered as communication tools between cells.
There have been reports demonstrating that exosomes released from highly malignant cancer cells can influence less malignant cells, altering their properties.
The transfer of microRNA and messenger RNA by exosomes into cells can significantly enhance the effects of skin regeneration therapy, the definitive form of pyramid-type skin regeneration treatment, thereby greatly reducing aging effects.
Exosome treatment regenerates the skin and provides an almighty effect for beauty purposes.
By directly injecting exosomes into the skin using water photo injection, etc., it is effective against all kinds of symptoms and concerns such as aging effects, wrinkles, sagging, enlarged pores, acne scars, and crater skin, achieving fundamental treatment.
Promotes cell activation from the dermal layer to the skin surface
Injecting exosomes derived from young human sources achieves fundamental treatment in skin regeneration through the fibers produced by cell division, so it is no exaggeration to say that only Four Seasons can provide the reassuring and trustworthy exosome injection for skin rejuvenation, addressing severe issues such as previously abandoned severe acne scars, craters, deep pores, and wrinkles.※Combining exosome injection with Dermapen treatment or exosome MESOGUN treatment can further enhance the effectiveness.
Exosomes promote relaxation of inflammation sites and suppress pain
Joint pain, back pain, neck pain, muscle pain, etc.
Improving immunity and activating cell division in damaged tissues and nerves by acting on cells with exosomes
Promotes cell division activation in tissues and nerves damaged by exosomes. It helps recover from liver diseases (cirrhosis, chronic hepatitis, etc.), skin diseases, respiratory diseases, kidney dysfunction, complications of diabetes, etc., as well as recovery from vision loss, Alzheimer’s disease, dementia, etc. from cells level. Through exosome drip therapy, exosomes are instantly transmitted through the blood to cells throughout the body, allowing the exosomes to be distributed throughout the body, leading to the recovery of various weakened organs and recover tissues with decreased functionality.
Suppresses allergies caused by abnormal immune reactions and regulates immunity
Allergic rhinitis/atopic dermatitis
Exosome MSC regeneration therapy is expected to be applied to a variety of treatments in addition to treatments to maintain beautiful skin.
Exosome MSC regeneration therapy
Before
After
At Four Seasons Cosmetic Dermatology, we can provide different types of exosomes to suit various symptoms.
We have introduced exosome preparations (SCS) derived from fat, dental pulp, and umbilical cord, including「human placenta-derived exosomes」,which are expected to be effective for the first time in Japan.
Effects can be expected with just 1 time treatment, but the injection method and number of treatments will vary depending on individual symptoms and physical condition. For more information, please contact your counselor.
Treatment methods used for skin regeneration, etc.
Treatment method injected into the skin
Exosomes have the function of carrying「information」to cells.
Information contains instructions for cells, and cells function based on instructions by receiving information.
However, because the entrance to a cell is very small and there is only one entrance, it is not easy to pass information to the cell.
Normally, information passes to cells only when it accidentally enters the entrance.
However, by attaching to cells, exosomes are able to pass information to cells regardless of the entrance.
For this reason, by using exosome water light injection as the basis for skin regeneration pyramid treatment, the effect of PRP skin regeneration increases the ability to pass information to cells, thereby raising the level of regeneration ability.
【Effects】Almighty improvement for all skin problems, including rejuvenating skin, facial proportions, wrinkles, sagging, firmness, lift-up, acne scars, acne scar craters, inflammation and suppuration, pores, fine wrinkles, mole, firmness, anti-aging
Water light injection (300 shots injected into the entire face with 9 needles)
MESOGUN injection (inject exosomes into the dermal layer and simultaneously treat wounds with MESOGUN to maximize natural healing power)
Water light injection (more than 300 shots of exosomes injected into the entire face with 9 needles)
【Treat the wound with Dermapen 4 and inject exosomes with water light injection】
Dermapen wound treatment for the following symptoms:
【Effects】Widespread severe acne scars, crater skin, dents, pores, noticeable acne scars, and deep wrinkles on the entire face
Furthermore, for partial dents like the one below, which had been given up on, using a MESOGUN to strengthen the wound.
In particular, we recommend MESOGUN wound treatment injections for the following symptoms:
【Effects】Particularly noticeable acne scars, crater skin, dents, bumpy acne scars, pores, deep wrinkles, sagging pores
【MESOGUN injection of exosomes】
Exosomes are injected with a single needle while continuously injecting only the particularly severe acne scars, craters, and pores with a MESOGUN.
Fundamental treatment of acne scars, crater skin, and pores that had been given up on by injecting exosomes with water-light injection and damaging them with Derma pen at the same time.
Derma pen (wound treatment)
Injecting exosomes with water-light injection
Double effect of injecting exosomes with water light injection and dermapen wound treatment
Hydrophotonic injection that allows exosomes to be injected into the dermal layer
MESOGUN injection (inject exosomes into the dermal layer and simultaneously treat wounds with MESOGUN to maximize natural healing power)
The exosome product used at Four Seasons Dermatology is a granular substance with a diameter of 50-150nm (nanometers: one billionth of a meter) secreted by cells. It contains lipids and proteins derived from cell membranes on its surface, while its interior contains substances such as nucleic acids (microRNA, messenger RNA, DNA) and proteins from within the cell. The exosome product introduced at our clinic is manufactured in a Class 1000 cleanroom. We adhere to stringent safety standards, following similar manufacturing procedures as those used for stem cell therapies and commissioning third-party quality inspections.
At Four Seasons Dermatology, the exosomes we introduce are supernatants (SCS) used to culture stem cells. To ensure your peace of mind when considering treatment, we pay close attention to the quality and safety management of our products.
Completely exclude toxic ingredients specified by the Globally Harmonized System of Classification and Labelling of Chemicals (GHS).
The culture medium is entirely original, with complete control over safety and hygiene management from startup to ensure product safety as much as possible.
We use AOF medium that excludes animal-derived ingredients and make efforts to eliminate the risk of pathogen infection while minimizing the quality differences between batches.
Yes, there may be some pain. As needles are used, there may be a prickling sensation, and we will administer anesthesia before the procedure.
Yes, possible side effects include bleeding, bruising at the injection site, fever, dizziness, allergic reactions, etc. If you have any concerns, please feel free to inform us during the pre-treatment consultation.
The treatment frequency is usually around once a month. The number of sessions depends on the desired outcome, and we will provide recommendations based on pre-treatment consultations and assessments.
Most people experience results within 1 week to several weeks after injection. ※Individual differences may affect the extent of change.
High concentration exosome premium(Exosome content 130-170 billion/vial)
Set | When added with stem cell treatment + special course (pyramid course) Human placenta-derived exosomes/fat-derived exosomes | ¥396,000(1Vial2cc) |
When added as a set with either PRP skin regeneration therapy (1 course 3 times) or ACRS therapy (1 course 3 times) Human placenta-derived exosomes/fat-derived exosomes | ¥496,100(1Vial2cc) | |
Single | Injection into the skin (water light injection/MESOGUN) | ¥660,000(1Vial2㏄) |
*The discount rate increases by 5% for each 2cc increase in the set.
*Set price does not include special course/pyramid course/ACRS therapy/PRP skin regeneration therapy.
*At our clinic, we only perform injections into the skin and do not administer intravenous drips.
*A separate needle fee (water light injection/MESOGUN/32G injection needle) is required for single use (injection into the skin).
*Anesthesia fee included
The following people cannot undergo treatment using exosomes.
Exosome therapy may have the following side effects. *Those who have received an injection or intravenous drip cannot donate blood for 3 months.
Tokyo Clinic | |||||||||||||||||||||||||
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Address | 〒105-0022 1-10-30 Kaigan, Minato-ku, Tokyo Atre Takeshiba Tower Building 3FGoogle Map |
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Access | 6 minutes walk from Hamamatsucho Station 3 minutes walk from Takeshiba Station |
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Telephone number | 03-6803-4908 | ||||||||||||||||||||||||
HP | https://tokyo.four-seasons.jp/en | ||||||||||||||||||||||||
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Four Seasons Cosmetic Dermatology Ginza (Counseling Room) | |||||||||||||||||||||||||
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Address | 〒104-0061 Okura Annex 5F, 3-4-1 Ginza, Chuo-ku, Tokyo Google Map |
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Access | 4 minutes walk from Tokyo Metro Ginza Line/Marunouchi Line/Hibiya Line 「Ginza Station」 5 minutes walk from Yurakucho Station on the JR/Tokyo Metro Yurakucho Line |
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Telephone number | 03-6893-2926 | ||||||||||||||||||||||||
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Kobe central clinic | |||||||||||||||||||||||||||||||||
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Address | 〒650-0001 6-6-1 Kanocho, Chuo-ku, Kobe City, Hyogo Prefecturer Kanazawa Sannomiya Building 8F Google Map |
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Access | 5 minutes walk from Sannomiya Line | ||||||||||||||||||||||||||||||||
Telephone number | 078-321-1121 | ||||||||||||||||||||||||||||||||
HP | https://four-seasons.jp/ | ||||||||||||||||||||||||||||||||
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Kobe 2nd clinic | |||||||||||||||||||||||||
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Address | 〒650-0012 1-20-13 Kitanagasadori, Chuo-ku, Kobe, Hyogo Prefecture Kitanosaka Ichibankan 7th floor Google Map |
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Access | 3 minutes walk from Sannomiya Line | ||||||||||||||||||||||||
Telephone number | 078-595-9606 | ||||||||||||||||||||||||
HP | https://four-seasons.jp/ | ||||||||||||||||||||||||
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